Endocrine Abstracts

Background: Chronic hypophosphataemia due to renal phosphorus wasting results in bone disease (rickets and osteomalacia). The principal regulators of renal phosphorous handling are parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23). X-linked hypophosphatemic (XLH) rickets is the most common genetic disorder of renal phosphorus wasting; acquired disorders include tumour-induced osteomalacia (TIO). The aims of this study were: i) to assess the clinical utility of ...

Vitamin D (VD) deficiency (25 OHD < 50 nmol/l) is common is chronic liver disease at 64%–92% regardless of aetiology. The only guidelines for routine VD supplementation are for cholestatic (C) liver disease; a population considered being at high risk of low bone mineral density (BMD). BMD decreases further following orthotopic liver transplant (OLT). To assess VD intake in an at risk population, retrospective analysis of intake was performed in OLT patients with C liv...

Bone turnover markers (BTMs) may have a role in assessing bone turnover and response to intervention in Paget’s disease. We examined the clinical utility of bone turnover markers at diagnosis through analysis of our database of patients with radiographically confirmed Paget’s disease.We identified 36 patients (20 men); mean age at diagnosis was 71.6 years (range 54–84). Radionuclide imaging identified that 64% had polyostotic disease, with...

Introduction: Fibroblast growth factor 23 (FGF23) excess is the cause of chronic hypophosphatemia in rare conditions such as X-linked hypophosphataemic rickets (XLHR) and tumour-induced osteomalacia (TIO), but animal studies indicate that the effect of FGF23 on serum phosphorus is dependent on the presence of parathyroid hormone (PTH). In this case series of rare disorders with abnormalities in renal phosphorus handling, we sought to explore the relative roles of PTH and FGF23...